Effect of enhancers on permeation kinetics of captopril for transdermal system

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B G Desai
A R Annamalai
B Divya
B M Dinesh

Abstract

Transdermal drug delivery system has seen a veritable explosion in the past decades. In the present scenario, very few transdermal patches are commercially available. The captopril being an antihypertensive drug requires chronic
administration. Since the drug has an extensive first-pass metabolism, an attempt was made to develop transdermal drug delivery system for better patient compliance. In this study, flux and permeation enhancement trials of captopril were carried out using modified Franz diffusion cells through siloxane membrane for 8 h. Citral and dimethyl formamide as permeation enhancers showed the best permeability as compared to sodium tauroglycholate, sodium lauryl sulfate, etc. One longstanding approach for improving transdermal drug delivery uses penetration enhancers (also called sorption promoters or accelerants), which penetrate into skin to reversibly decrease the barrier resistance.

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How to Cite
Desai, B. G., Annamalai, A. R., Divya, B., & Dinesh, B. M. (2014). Effect of enhancers on permeation kinetics of captopril for transdermal system. Asian Journal of Pharmaceutics (AJP), 2(1). https://doi.org/10.22377/ajp.v2i1.169
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References

Hadgraft J, Lane ME. Skin permeation: The years of enlightenment. Int

J Pharm 2005;305:2-12.

Bruton LL, Laza JS, Parker KL. Goodman Gilman’s: The pharmacological

basis of therapeutics. New York: McGraw Hill Medical Publishing

Division; 2006. p. 801-10.

Martindale: The complete drug reference. The enhancement effect of

surfactants on the penetration of lorazepam through rat skin. 33rd ed.

London: Pharmaceutical Press; 2007. p. 853-4.

Nokhodchi A, Shokri J, Dashbolaghi A, Hassan-Zadeh D, Ghafourian T,

Barzegar-Jalali M. The enhancement effect of surfactants on the penetration of lorazepam through rat skin. Int J Pharm 2003;250:359-69.

Sutariya V, Mashru R, Sunkalia MS. Transbuccal delivery of lomotrigine

across procine buccal mucosa in vitro determination of roots of buccal

transport. J Pharm Sci., 2005;8:54-62.

Mashru R, Sutariya V, Sankalia M, Sankalia J. Transbuccal delivery of

lamotrigine across porcine buccal mucosa: In vitro determination of

routes of buccal transport. J Pharm Pharma Sci 2005;8:54-62.

Shah JC, Ross JS. Reduction in skin permeation of n,n-diethyl-

m-toluamide by altering the skin/vehicle partition co-efficient. J Control

Release 2000;67:211-21.

Pugh WJ, Hadgraft J. Prediction of human skin permeability coefficients.

Int J Pharm 1994;103:163-78.

Hadgraft J, Lane ME. Skin permeation: The years of enlightenment. Int

J Pharm 2005;305:2-12.

Nanayakkara GR, Bartlett A, Forbes B, Marriott C, Whitfield PJ,

Brown MB. The effect of unsaturated fatty acids in benzyl alcohol

on the percutaneous permeation of three model penetrants. Int J

Pharm 2005;301:129-39.

Ghafourian T, Zandasrar P, Hamishekar H, Nokhodchi A. The effect of

penetration enhancers on drug delivery through skin: A QSAR study.

J Control Release 2004;99:113-25.

Hadgraft J. Skin deep. Eur J Pharm Biol 2004;58:291-9.

Kanikkannan N, Singh M. Skin permeation enhancement effect and skin irritation of saturated fatty alcohols. Int J Pharm 2002;248:219-28.

Akimoto T, Kawahara K, Nagase Y, Aoyagi T. Polymeric transdermal drug penetration enhancer: The enhancing effect of oligodimethylsiloxane

containing a glucopyranosyl end group. J Control Release 2001;77:

-57.

Copoví O, Díez-Sales JV, Herráez-Domínguez, Herráez-Domínguez M.

Enhancing effect of alpha-hydroxyacids on “in vitro†permeation across

the human skin of compounds with different lipophilicity. Int J Pharm

;314:31-6.

Nokhodchi A, Shokri J, Dashbolaghi A, Hassan-Zadeh D, Ghafourian T,

Barzegar-Jalali M. The enhancement effect of surfactants on the

penetration of lorazepam through rat skin. Int J Pharm 2003;250:

-69.

Hadgraft J. Passive enhancement strategies in topical and transdermal

drug delivery. Int J Pharm 1999;184:1-6.