Quantitative spectrophotometric estimation of cefadroxil using hydrotropic solubilization technique

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Ravi S Shukla
Asha Patel
M L Soni
Vishesh Modi
Y A Jaliwala


Hydrotropy is one of the reliable methods to enhance aqueous solubility of poorly soluble drugs. In the present investigation, hydrotropic solution of urea (6 M) was employed as a solubilizing agent to solubilize the poorly water- soluble drug, cefadroxil, in the tablet form and determined with the help of spectrophotometric determination in ultraviolet region. In solubility determination study, it was found that there was more than 10-fold enhancement in solubility of cefadroxil
in 6-M urea solution. Cefadroxil showed maximum absorption at 263 nm and obeyed Beer’s law in concentration range of 10-80 μg/ml. Results of analysis were validated statistically and by recovery studies. The proposed method is new, simple,
eco-friendly, economic, and accurate and can be utilized in routine analysis of cefadroxil tablets.


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How to Cite
Shukla, R. S., Patel, A., Soni, M. L., Modi, V., & Jaliwala, Y. A. (2014). Quantitative spectrophotometric estimation of cefadroxil using hydrotropic solubilization technique. Asian Journal of Pharmaceutics (AJP), 2(3). https://doi.org/10.22377/ajp.v2i3.185


Maheshwari RK. Spectrophotometric determination of cefixime in

tablets by hydrotropic solubilization phenomenon Indian Pharmacist


Maheshwari RK. Analysis of frusemide by application of hydrotropic

solubilization phenomenon, Indian Pharmacist 2005;4:55.

Maheshwari RK. A novel application of hydrotropic solubilization in

the analysis of bulk samples of ketoprofen and salicylic acid Asian J

Chem 2006;18:393.

Maheshwari RK, Chaturvedi SC, Jain NK. Application of hydrotropy in

spectrophotometric determination of pharmaceutical dosage forms,

Indian Drugs 2005;42:760.

Maheshwari RK. New application of hydrotropic solubilization in the

spectrophotometric estimation of ketoprofen in tablet dosage fThe

Pharma Rev 2005;3:123.

Jain NK, Agarwal RK, Singhai AK. Formulation of aqueous injection of

carbamazepine. Pharmazie 1990;45:221-2.

Darwish IA, Florence AT, Saleh AM. Novel application of hydrotropic

solubilization in the spectrophotometric analysis J Pharm Sci


Coffman RE, Kildisg DO. Effect of nicotinamide and urea on the solubility

of riboflavin in various solvents. J Pharm Sci 1996;85:951-4.

Poochikian GD, Gradock JC. Enhanced chartreusin solubility by

hydroxybenzoate hydrotropy. J Pharm Sci 1979;68:728-32.

Ueda S. The mechanisms of solubilization of water insoluble substances

with sodium benzoate derivatives-I, Chem Pharm Bull 1966;14:22.

Etman MA, Hada AH, Hydrotropic and cosolvent solubilization of

indomethacin, Acta Pharm 1999; 49:291.

Agrawal S, Pancholi SS, Jain NK, Agrawal GP. Hydrotropic solubilization of nimesulide for parenteral administration. Int J Pharm 2004;274:149-55.

Simamora P, Alvarez JM, Yalkowsky SH. Solubilization of rapamycin. Int J Pharm 2001;213:25-9.