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The drug was targeted to the colon and their aligned area for their local effect. Aceclofenac was microencapsulated with Eudragit (S 100, RL 100, and RS 100), using an O/W emulsion-solvent evaporation technique. Aceclofenac microspheres
were subjected to micromeritic properties including angle of repose, bulk density, tapped density, Carrâ€™s index, Hausnerâ€™s ratio, and particle size determination. Microspheres were subjected to drug loading, in vitro drug release as well as for
scanning electron microscopy.The prepared microspheres were white, free-flowing, and almost spherical in shape.The drug- loaded microspheres show 60-82% drug entrapment, angle of repose was in the range of 16.13 Â± 0.621-24 Â± 0.590, bulk
and tapped densities respectively were in the range of 0.311 Â± 0.006-0.562 Â± 0.012 and 0.373 Â± 0.01-0.735 Â± 0.02, Carrâ€™s index ranges from 14.04 Â± 0.026 to 27.25 Â± 1.405, Hausnerâ€™s ratio was 1.14 Â± 0.026-1.37 Â± 0.03, and particle size was in the range of 79.7016-144.840 Î¼m. In vitro drug release studies were carried out up to 24 h in three different pH media, i.e., 0.1 N HCl (pH 1.2), phosphate buffer (pH 6.8), and phosphate buffer (pH 7.4). The drug-polymer concentration of dispersed phase influences the particle size and drug release properties. All the formulations at higher pH were followed
by the Matrix-Higuchi model.
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