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in elderly and pediatrics. Unfortunately, a high percentage of patients suffering from type-2 diabetes are elderly people showing dysphagia. In this study, orally disintegrating tablets were prepared using direct compression and wet granulation method. First, the tablets of metformin were prepared using starch RX1500 and microcrystalline cellulose by direct compression. The tablets showed erosion behavior rather than disintegration. Then lactose was incorporated which created pores to cause burst release of drug. But these tablets did not give good mouth feel. Thus, Pearlitol SD 200 (spray dried mannitol) was used to prepare tablets by wet granulation (10% polyvinylpyrrolidone in Isopropyl alcohol as binder). The optimized batches of tablets (LMCT3 and MP13) not only exhibited desired mouth feel but also disintegration time, in vitro dispersion time, water absorption ratio, and in vitro drug release. All the batches contained 15% starch 1500 and 4% of croscarmellose sodium. The optimized batches prepared by direct compression and wet granulation showed 85% drug release at 4 min and 8 min,
respectively. The strong saline and slight bitter taste of the drug was masked using nonnutritive sweetener and flavor.
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Bhusan SY, Sambhaji SP, Anant RP, Kakasaheb RM. New drug delivery
system for elderly. Indian Drugs 2000;37:312-8.
Wadhwani AR, Prabhu NB, Nandkarni MA, Amin PD. Consumer friendly
mucolytic formulations. Indian J Pharma Sci 2004;7:506-7.
Hausler, Franz, Rohrich, Till, Effervescent Metformin composition and
tablets, granules there from, 2007, WO/ 038979 A1.
Chandran R, Gogia A. Liquid formulation of Metformin 2005. U.S Patent
No, 6,890,957 B2.
Lachman L, Lieberman HA, Kanig JL. The theory and practice of
industrial pharmacy. 3rd ed. Mumbai: Varghese Publishing House; 1987.
p. 182-184, 296-303, 311-312.
Indian Pharmacopoeia. Vol. 2. New Delhi: Controller of Publication;
Gohel MC, Bansal G, Bhatt N. Formulation and evaluation of
orodispersible taste masked tablets of Famotidine. Pharma Biol World
Khar R. Taste masking technologies in oral pharmaceuticals: Recent
development and approaches. Drug Dev Ind Pharm 2004;30:429-48.
Starch 1500Â® Partially Pregelatinized Maize starch- the superior
multifunctional excipient for solid dosage development, Colorcon
Technical literature, Colorcon Asia, Goa, India.
Shirwaikar AA, Shirwaikar A, Kumar R, Prabhu SL, Mahalaxmi R.
Formulation and evaluation of mouth dissolving tablets of Metformin.
Int J Pharma Excip 2006;July-Sept: 86-92