Development and evaluation of xyloglucan matrix tablets containing naproxen

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R V Kulkarni
Anirudh Shah
Rashmi Boppana


The xyloglucan (XGL) matrix tablets containing naproxen were prepared by conventional wet granulation technique
and evaluated for its drug release characteristics. Hardness of the tablets was found to be in the range of 5.0-7.0 kg/
cm2. The tablets showed 98.23-99.12% of the labeled amount of drug, indicating uniformity in drug content. The swelling
index increased with the increase in concentration of XGL and with the addition of hydroxypropylmethyl cellulose (HPMC)
in the matrices, whereas swelling index decreased with the addition of cellulose acetate phthalate (CAP) and ethyl cellulose
(EC). The compaction pressure had no significant effect on the drug release. Increase in polymer content and increased
initial drug loading resulted in decreased drug release from the tablets. Addition of HPMC, CAP, and EC to XGL tablets
decreased the drug release, and release was extended over a period of 8 h. The mechanism of release from all the tablets
deviated from Fickian mode.
Key words: Drug release, matrix tablets, naproxen, xyloglucan


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Kulkarni, R. V., Shah, A., & Boppana, R. (2014). Development and evaluation of xyloglucan matrix tablets containing naproxen. Asian Journal of Pharmaceutics (AJP), 2(2).


Colombo P, Bettini R, Massimo G, Catellani PL, Santi P, Peppas NA. Drug

diffusion front movement is important in drug release control from

swellable matrix tablets. J Pharm Sci 1995;84:991-7.

Vazquez MJ, Perez-Marcos B, Gomez-Amoza JL, Martines, Pacheco R,

Souto C, et al. Influence of technological variables on release of drugs

from hydrophilic matrices. Drug Dev Ind Pharm 1992;18:1355-75.

Bonferoni MC, Rossi S, Tamayo M, Pedraz JL, Dominguez Gil A,

Caramella C. On the employment of l-Carrageenan in a matrix

system I. Sensitivity to dissolution medium and comparison with

Na carboxymethyl cellulose and Xanthan gum. J Control Release


Ford JL, Ribinstein MH, McCaul F, Hogan JE, Edgar PJ. Importance of drug

type, tablet shape and added diluents on drug release kinetics from

hydroxypropyl methyl cellulose matrix tablets. Int J Pharm 1987;40:


Talukdar MM, Plaizier-Vercammen J. Evaluation of xanthan gum as a

hydrophilic matrix for controlled release dosage form preparations.

Drug Dev Ind Pharm 1993;19:1037-46.

Risk S, Duru D, Gaudy D, Jacob M. Natural polymer hydrophilic matrix:

influencing drug release factors. Drug Dev Ind Pharm 1994;20:2563-74.

Sujja-areevath J, Munday DL, Cox PJ, Khan KA. Release characteristics

of diclofenac sodium from encapsulated natural gum mini-matrix

formulations. Int J Pharm 1996;139:53-62.

Khullar P, Khar RK, Agarwal SP. Evaluation of guar gum in the preparation

of sustained-release matrix tablets. Drug Dev Ind Pharm 1998;24:


Rao PS, Ghosh TP, Krishna S. Extraction and purification of tamarind

seed polysaccharide. J Sci Ind Res 1946;4:705.

Sano M, Miyata E, Tamano S, Hagiwara A, Ito N, Shirai T. Lack of

carcinogenicity of tamarind seed polysaccharide in B6C3F mice. Food

Chem Toxicol 1996;34:463-7.

Burgalassi S, Panichi L, Saettone MF, Jacobsen J, Rassing MR. Development

and in vitro/in vivo testing of mucoadhesive buccal patches releasing

benzydamine and lidocaine. Int J Pharm 1996;133:1-7.

Rao PS, Srivastava HC. Tamarind in industrial gums. In: Whistler RL,

editor. 2nd ed, New York: Academic Press; 1973. p. 369-411.

Meier H, Reid JS. Reserve polysaccharides other than starch in higher

plants in Encyclopedia of plant physiology, NS: Plant Carbohydrates I:

Intracellular carbohydrates. In: Loewus FA, Tanner W, editors. Vol. 134,

Springer- Verlag; 1982. p. 418-71.

Gerard T. Tamarind Gum In Handbook of water-soluble gums and

resins. In: Davidson RL, editor. USA: McGraw-Hill Book Co; 1980.

p. 23.1-23.12.

Gidley MJ, Lillford PJ, Rowlands DW. Structural and solution properties of

tamarind-seed polysaccharide. Carbohydrate Res 1991;214:299-314.