Formulation and evaluation of controlled release floating matrix tablets of Stavudine

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Suryadevara Vidyadhara
Irukulapati Nagendran
Reddyvalam Lankapalli C. Sasidhar
Vallabhaneni Akhila Devi
Kadiyala Swapna


The purpose of this research was to prepare and evaluate floating drug delivery systems of Stavudine. Floating matrix tablets of Stavudine were developed to prolong gastric residence time and increase its bioavailability. Rapid gastrointestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose. The matrix tablets were prepared by direct compression technique, using polymers such as hydroxylpropylmethyl cellulose (HPMC K15M), karaya gum and other standard excipients. Sodium bicarbonate was
incorporated as a gasâ€generating agent.The effect of different concentrations of polymers on drug release profile and floating properties were investigated. Comparable release profiles between the commercial product and the designed system were obtained. The matrix formulations were evaluated for physical parameters, drug release by in vitro dissolution studies and in vitro buoyancy studies. Surface characteristics, drugâ€excipient interactions and crystal morphology of optimized formulations were evaluated by SEM analysis and DSC studies.


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Vidyadhara, S., Nagendran, I., C. Sasidhar, R. L., Devi, V. A., & Swapna, K. (2014). Formulation and evaluation of controlled release floating matrix tablets of Stavudine. Asian Journal of Pharmaceutics (AJP), 6(4).


Chien YW. Novel drug delivery systems. 2nd ed. NY: Marcel Dekker, Inc.;

Robinson JR, Lee VH. Controlled drug delivery fundamentals and

applications. New York: Marcel Dekker; 2005. p. 40â€1.

Ritschel WA, Kearns GL. Absorption/transport mechanisms, in handbook

of basic pharmacokinetics including clinical applications. Washington,

DC: American Pharmaceutical Association; 1999. p. 63.

Harder S, Furh U, Bergmann D. Ciprofloxacin absorption in different

regions of the human GIT, investigation with the Hf Capsule. Br J Clin

Pharma col 1990;30:35â€9.

Rouge N, Buri P, Doelkar E. Drug absorption site in the gastrointestinal

tract and dosage forms for siteâ€specific delivery. Int J Pharm


Chungi VS, Dittere LW, Smith RB. Gastrointestinal sites for furosemide

absorption in rats. Int J Pharm 1979;4:27â€38.

Drewe J, Beglinger C, Kissel T. The absorption site of cyclosporin in

human GIT.Br J Clin Pharmacol 1992;33:39â€43.

Cremer K. Drug delivery: Gastroâ€remaining dosage forms. The Pharm J


Kohri N. Improving the oral bioavailability of sulpiride by gastricâ€retained form in rabbits. J Pharm Pharmacol 1996;48:371â€4.

Singh BN, Kim KH. Floating drug delivery systems: An approach to

oral controlled drug delivery via gastric retention. J Control Release


Agyilirah GA, Green M, Durect R. Evaluation of the gastric retention

properties of a cross linked polymer coated tablet versus those of a

non disintegrating tablets. Int J Pharm 1991;75:241â€7.

Streubel A, Siepmann J, Bodmaier R. Drug delivery to the upper small

intestine window using gastroretentive technologies. Curr Opin

Pharmacol 2006;6:501â€8.

Larhed AW, Artursson P, Grasjo J, Bjork K. Diffusion of drugs in native

and purified gastrointestinal mucus. J Pharm Sci 1997;86:660â€5.

Hoffman F, Pressman JH, Code CF. Controlled entry of orally

admnistered drugs, physiological considerations. Drug Dev Ind Pharm


Davis SS, Stockwell AF, Taylor MJ, John GH, David RW, Wilson CG, et al.The effect of density on the gastric emptying of single and multiple

unit dosage forms. Pharm Res 1986;3:208â€13.

Arrora S, Ali J, Khar RK, Baboota S. Floating drug delivery systems:

A review. AAPS Pharm Sci Tech 2005;6:372â€90.

The Indian Pharmacopoeia. Indian Pharmacopoeia Commission, Govt.

of India, Vol III. 2010:2149-50.

Higuchi T. Mechanism of rate of sustained action medication. J Pharm

Sci 1963;52:1145â€9.

Peppas NA, Sahlin JJ. A simple equation for the description of

solute release III. Coupling of diffusion and relaxation. Int J Pharm


Chien YW, Shoufeng Li, Lin S, Daggy BP. Effect of formulation variables

on the floating properties of gastric floating drug delivery system. Drug

Dev Ind Pharm 2002;28:783â€93.

Chavanpatil DM, Jain P, Choudhari S, Shear R, Vavia RP. Novel sustained release, swellable and bioadhesive gastro retentive drug delivery system for Ofloxacin. Int J Pharm 2006;316:86â€92.