Formulation development of Domperidone buccal bioadhesive hydrophilic matrix tablets

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Ashwini R Madgulkar
Mangesh R Bhalekar
Amruta S Ner
Nitin D Wable


Buccoadhesives have long been employed to improve the bioavailability of drugs undergoing significant hepatic first pass metabolism. Domperidone is also reported to have low oral bioavailability due to an extensive hepatic first-pass
effect. Buccoadhesive hydrophilic matrices containing Domperidone were prepared using a 32 factorial design.The amounts of Carbopol 934P (CP) and Methocel K100LV (HPMC) were taken as the formulation variables (factors) for optimizing
bioadhesion and kinetics of dissolution. A mathematical model was generated for each response parameter. Bioadhesive strength tended to vary quite linearly in an increasing order with an increasing amount of each polymer. The drug release pattern for all the formulation combinations was found to be non Fickian, approaching zero-order kinetics. A suitable combination of two polymers provided adequate bioadhesive strength and fairly regulated the release profile up to 4 hr. The response surfaces and contour plots for each response parameter are presented for further interpretation of the results.The optimum formulations were chosen and their predicted results were found to be in close agreement with the experimental findings.


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Madgulkar, A. R., Bhalekar, M. R., Ner, A. S., & Wable, N. D. (2014). Formulation development of Domperidone buccal bioadhesive hydrophilic matrix tablets. Asian Journal of Pharmaceutics (AJP), 5(1).


McElnay JC. Buccal Absorption of Drugs. In: Swarbrick J, Boylan JC,

editors. Encyclopedia of Pharmaceutical Technology. Vol. 2. New York;

Marcel Dekker; 1990. p. 189-211.

Rathbone MJ, Drummond BK, Tucker IG. The Oral Cavity as a Site for

Systemic Drug Delivery. Adv Drug Del 1994;13:1-22.

Chidambaram N, Srivatsava AK. Buccal Drug Delivery Systems. Drug

Dev Ind Pharm 1995;21:1009-36.

Khanna R, Agarwal SP, Ahuja A. Mucoadhesive Buccal Drug Delivery:

A Potential Alternative to Conventional Therapy. Indian J Pharm Sci


European pharmacopoeia. 3rd ed. Strasbourg: Council of Europea,

Strasbourg; 1997. p. 779-80.

British Pharmacopoeia. Vol. 1. London: HMSO; 2001. p. 215.

Tripathi KD. Essentials of Medical Pharmacology. 4th ed. New Delhi:

Jaypee Brothers Medical Publishers (P) Ltd; 1999. p. 649-50.

Budavari S. The Merck Index. 11th ed. Merk and Co. Inc, USA. 1989.

p. 3412.

Vatsraj NB, Zai H, Needham T. Formulation and Optimization of a

Sustained Release Tablet of Ketorolac Tromethamine. Drug Deliv


Gohel MC, Amin AF. Formulation design and Optimization of Modified-

Release Microsphere of Diclofenac Sodium. Drug Dev Ind Pharm


Doornbos DA, Haan P. Optimization Techniques in formulation

and Processing. In: Swarbrick J, Boylan JC, editors. Encyclopedia of

Pharmaceutical technology. Vol. 11. New York: Marcel Dekker; 1995.

p. 77-160.

Singh B, Ahuja N. Book Review on pharmaceutical Experimental Design. Int J Pharm 2000;195:247-8.

Bolton S. Optimization techniques. Pharmaceutical statistics: Practical and Clinical Applications. 2nd ed. New York: Marcel Dekker; 1990. p. 532-70.

Ketteneh-Wold N. Use of Experimental Design in the Pharmaceutical

industry. J pharm Biomed Anal 1991;9:605-10.

Gupta A, Garg S, Khar RK. Measurement of Bioadhesive Strength of

Mucoadhesive Buccal tablets: Design of an In vitro Assembly. Indian

Drugs 1993;30:152-5.

Singh B, Singh SA. Comprehensive Computer Program for the Study

of Drug Release Kinetics from Compressed Matrices. Indian J Pharm

Sci 1998;60:358-62.

Singh B, Kaur T, Singh S. Correction of Raw Dissolution Data for Loss of Drug and Volume During Sampling. Indian J Pharm Sci 1997;59:196-9.

Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms

of Solute Release from Porous Hydrophilic Polymers. Int J Pharm


Gupta A, Garg S, Khar SR. Mucoadhesive Buccal drug delivery system-A Review. Indian Drugs 1992;29:586-93.

Harris D, Robinson JR. Drug Delivery via the mucous membrane of oral cavity. J Pharm Sci 1992;81:1-10.

Chowdary DPR, Srinivas L. Mucoadhesive drug delivery system: A review current status. Indian Drugs 2000;37:400-6.