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drug were prepared using different combinations of polymers and plasticizers EudragitÂ® EPO, HPMC E 5 LV, and PVA were the selected polymers. Glycerin, dibutyl phthalate, propylene glycol, and PEG 400 were the selected plasticizers.The resultant films were evaluated for weight variation, assay, content uniformity, folding endurance, thickness, tensile strength, percent
elongation, surface pH, in vitro disintegration and in vitro dissolution.The formulations from the preliminary trial were analyzed using Taguchi OA experimental design, which was applied to optimize the type of polymers, concentration of polymers, plasticizer, and sweetener based on their disintegration data at three different levels.The optimized films disintegrated in less
than 30s, releasing 70-90% of drug within 2 mins.The percentage release varied with the type of polymer and concentration of polymer. The films made with EPO released 96% of drug in 2 mins, which was the best release among all.
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Dixit RP, Puthli SP. Oral strip technology: Overview and future potential.
J Control Release 2009;139:94-107.
Cetrizine hydrochloride. In: Rang HP, Dale MM, Ritter JM, Moore PK,
editors. Pharmacology. 5th ed. Churchill Livingstone: An imprint of
Elsevier; 2005. p. 253.
Indian Pharmacopoeia. Vol 1. Delhi: Government of India ministry of
health and family welfare; 1996.
Chaudhari PD. Formulation and in vitro evaluation of taste masked
orodispersible dosage form of Levocetrizine dihydrochloride. Indian J
Pharm Sci 2007;41:319-27.
Ming J. Chen (firstname.lastname@example.org), Gloria Tirol, Robert Schmitt, Chiling
Chien, Ahmed Dualeh. Film-Forming Polymers in Fast-Dissolve Oral
Films. The Dow Chemical Company, Water Soluble Polymers. Bound
Brook, NJ: 08854; 2006.
Mahesh A, Shastri N, Sadanandam M. Development of taste masked
fast disintegrating films of levocetirizine dihydrochloride for oral use.
Curr Drug Deliv 2010;7:21-7.
United States Pharmacopoeia DI Drug information for health care
professionals. Vol 1A. 12th ed. By the authority of the United States
Pharmacopoeial Convention, Inc. 1992.
Repka MA, Kavitha G, Suneela P, Manish M, Stodghill SP. Characterization of cellulosic hot-melt extruded films containing lidocaine. Eur J Pharm Biopharm 2005;59:189-96.
Satishbabu BK, Srinivasan BP. Preparation and evaluation of
buccoadhesive films of atenolol. Indian J Pharm Sci 2008;70:175-9.
Mona SA, Semalty KG. Formulation and characterization of
mucoadhesive buccal films of glipizide. Indian J Pharm Sci 2008;70:43-8.
Iman IS, Nadia AS, Abdou Ebtsam M. Formulation and stability study of
Chlorpheniramine maleate transdermal patch. Asian J Pharm 2010;6:17-23.
Anand Babu D, Ramesh P. Development and characterization of
biodegradable chitosan films for local delivery of Paclitaxel. AAPS J
Malke S, Shidhaye S, Desai J, Kadam V. Oral films - patient compliant
dosage form for pediatrics. Int J Pediatr Neonatol 2010;11:2.
Borsadia SB, O'Halloran D, Osborne JL. Quick-dissolving films: A novel
approach to drug delivery. Drug Deliv Technol 2003;3:1.
Ahmed MG, Narayana CR, Harish NM, Prabhakar P. Formulation and
In-vitro evaluation of Chitosan films containing tetracycline for the
treatment of periodontitis. Asian J Pharm 2009;3:113-9.
Niamsa N, Baimark Y. Preparation and characterization of highly
flexible chitosan films for use as food packaging. Am J Food Technol
Cervera MF, Heinamaki J, Krogars K, Jorgensen AC, Karjalainen M,
Colarte AI, et al. Solid-state and mechanical properties of aqueous
chitosan-amylose starch films plasticized with polyols. AAPS
Patel AR, Dharmendra S, Jignyasha P, Raval A. Fast dissolving films (fdfs) as a newer venture in fast dissolving dosage forms. Int J Drug Deliv
Nishimura M, Matsuura K, Tsukioka T, Yamashita H, Naoki I, Sugiyama T,et al. In vitro and in vivo characteristics of prochlorperazine oral
disintegrating film. Int J Pharm 2009;368:98-102.
Shimoda H, Taniguchi K, Nishimura M, Matsuura K, Tsukioka T,
Yamashita H, et al. Preparation of a fast dissolving oral thin film
containing dexamethasone: A possible application to antiemesis during
cancer chemotherapy. Eur J Pharm Biopharm 2009;73:361-5.
Banker G. Film coating theory and practice. J Pharm Sci 1966;55:81-9.
Corniello C. Quick dissolving strips: From concept to commercialization.
Drug Del Technol 2006;6:68-71.
Frankhauser C, Slominski G, Meyer S. Disintegrable oral films. U.S.
Patent 2007/0202057, Aug 30, 2007.
Kayumba P, Huyghebaert N, Cordella C, Ntawukuliryayo J, Vervaet C,
Remon J. Quinine sulphate pellets for flexible pediatric drug dosing:
Formulation development and evaluation of taste-masking efficiency
using the electronic tongue. Eur J Pharm Biopharm 2007;66:460-5.
Wieland-Berghausen S, Schote U, Frey M, Schmidt F. Comparison of
microencapsulation techniques for the water-soluble drugs nitenpyram
and clomipramine HCl. J Control Release 2002;85:35-43.