Investigation of tablettability and drug release properties of ethyl cellulose

Main Article Content

Vinod L Gaikwad
Namdeo R Jadhav


The purpose of the present research is to investigate systematically the tablettability and drug release properties of ethyl cellulose (EC) in compact form. A total of nine batches of compacts containing metformin hydrochloride (MTF) as
model drug and ECs with varying viscosity grades (7, 10, and 100 cps) at 10, 20 and 30% w/w contents were prepared. Profound effect of viscosity grades and content of EC on compression behavior of granules and drug release from compacted matrices was observed. An increase in EC 7 cps content resulted improvement in tensile strength and compactibility. However, compression susceptibility gets inversely affected. EC 7 cps has shown MTF release, which is extended upto 10 hours (t90%), attributed to high interparticulate interactions. Similar trend was observed with both EC 10 cps (t90%; upto 13 hours) and 100
cps (t90%; upto 10 hours). Surprising results were observed for matrices of EC 10 cps at 20% w/w, which showed moderate compactibility and tensile strength, but extended the MTF release for maximum time among all compact formulations
(t90%; 13 hours; peppas model). These results show the use of EC 10 cps in formulations desired for extended drug release at its optimum content. Matrices containing EC 100 cps have shown better compressibility and compactibility among all batches. The anomalous behavior of high viscosity EC (at 20% w/w content) matrices releasing drug in shorter time (t90%, 8 hours; zero order) can be ascribed to poor matrixing of MTF in EC network due to high molecular weight of EC 100 cps.


Download data is not yet available.

Article Details

How to Cite
Gaikwad, V. L., & Jadhav, N. R. (2014). Investigation of tablettability and drug release properties of ethyl cellulose. Asian Journal of Pharmaceutics (AJP), 5(4).


Lin SY, Lin KH, Li MJ. Micronized ethyl cellulose used for designing a

directly compressed time controlled disintegration tablet. J Control

Release 2001;70:321-8.

Siepmann F, Hoffmann A, Leclercq B, Carlin B, Siepmann J. How to adjust desired drug release patterns from ethyl cellulose-coated dosage forms. J Control Release 2007;119:182-9.

Neau SH, Howard MA, Claudius JS, Howard DR. The effect of the

aqueous solubility of xanthine derivatives on the release mechanism

from ethylcelluse matrix tablet. Int J Pharm 1999;179:97-105.

Lovgren K, Lundberg PJ. Determination of sphericity of pellets

prepared by extrusion /spheronization and the impact of some process

parameters. Drug Dev Ind Pharm 1989;14-15:2375-92.

Dees PJ, Polderman J. Mercury porosimetry in pharmaceutical

technology. Powder Technol 1981;29:187-97.

Lowenthal W. Disintegration of tablets. J Pharm Sci 1972;61:1695-711.

Emeje MO, Kunle OO, Ofoefule SI. Compaction characteristics of ethyl cellulose in the presence of some channeling agents: technical note.

AAPS PharmSciTech 2006;7:E18-21.

Pather SI, Russell I, Syce JA, Neau SH. Sustained release theophylline

tablets by direct compression. Part 1: Formulation and in vitro testing.

Int J Pharm 1998;164:1-10.

Katikaneni PR, Upadrashta SM, Rowlings CE, Neau SH, Hileman GA.

Consolidation of ethylcellulose: Effect of particle size, press speed,

and lubricants. Int J Pharm 1995;117:13-21.

Katikaneni PR, Upadrashta SM, Neau SH, Mitra AK. Ethylcellulose

matrix controlled release tablets of a water-soluble drug. Int J Pharm


Desai J, Alexander K, Riga A. Characterization of polymeric dispersions

of dimenhydrinate in ethyl cellulose for controlled release. Int J Pharm


Mura P, Faucci MT, Manderioli A, Bramanti G, Parrini P. Thermal behavior and dissolution properties of naproxen from binary and ternary solid dispersion. Drug Dev Ind Pharm 1999;25:257-64.

Friedman M, Golomb G. New sustained release dosage form of

chlorhexidine for dental use. J Periodontal Res 1982;17:323-8.

Soskolne WA, Golomb G, Friedman M, Sela MN. New sustained

release dosage form of chlorhexidine for dental use. J Periodontal Res


Krycer I, Pope DG, Hersey A. An evaluation of the techniques employed to investigate powder compaction behavior. Int J Pharm 1982;12:113-34.

Heckel RW. Density-pressure relationships in powder compaction. Trans Mettall Soc AIME 1961;221:671-75.

Heckel RW. An analysis of powder compaction phenomena. Trans Mettall Soc AIME 1961;221:1001-8.

Rubinstein MH, Musikabhumma P. A universal friability test for tablet

granules. Pharm Acta Helv 1978;53:125-9.

Leuenberger H. The compressibility and compactibility of powder

systems. Int J Pharm 1982;12:41-55.

Leuenberger H, Jetzer W. The compactibility of powder systems- a novel

approach. Powder Technol 1984;37:209-18.

The indian pharmaceutical convention. Indian pharmacopoeia. 5th ed.

Ghaziabad: The Indian Pharmaceutical Commission; 2007. p. 1359.

Moffat AC, Osselton MD, Widdop B. Clarke’s analysis of drugs and

poisons. 3rd ed. London: Pharmaceutical Press; 2004. p. 1229.

Gokonda SR, Hileman GA, Upadrastha SM. Development of matrix

controlled release beads by extrusion-spheronization techniques

technology using a statistical screening design. Drug Dev Ind Pharm


Ahmed A, Souad S. Effect of viscosity grades of ethylcellulose on the

sustained release properties of indomethacin from its tablets matrix.

Afr J Pharm Pharmaco 2008;2:153-6.

Crowley MM, Schroeder B, Fredersdorf A, Obara S, Talarico M, Kucera S,et al. Physicochemical properties and mechanism of drug release fromethyl cellulose matrix tablets prepared by direct compression and hot-melt extrusion. Int J Pharm 2004;269:509-22.