Novel application of mixed hydrotropic solubilization technique in the formulation and evaluation of hydrotropic solid dispersion of aceclofenac

Main Article Content

Rajesh Kumar Maheshwari
Arpna Indurkhya


In the present investigation, newly developed mixed hydrotropic solid dispersion (HSD) technology precludes the use of organic solvent and also decreases the individual concentration of hydrotropic agents, simultaneously decreasing their
toxic potential. ‘Mixed-hydrotropic solubilization’ technique is the phenomenon to increase the solubility of poorly water- soluble drugs in the aqueous solution containing blends of hydrotropic agents, which may give synergistic enhancement effect on solubility of poorly water-soluble drugs and to reduce concentrations of each individual hydrotropic agent to minimize their toxic effects due to high concentration of hydrotropic agents. Maheshwari has made HSD of paracetamol using urea. In the present study, the aqueous solution of hydrotropic blend (20% urea and 10% sodium citrate) has been found to increase aqueous solubility of poorly water-soluble drug, aceclofenac. This mixedhydrotropic blend was used to prepare solid dispersion of aceclofenac. The prepared solid dispersions have been characterized by IR and XRD studies. They have been studied for dissolution rate enhancement effect. The prepared solid dispersions were found very stable (chemically).


Download data is not yet available.

Article Details

How to Cite
Maheshwari, R. K., & Indurkhya, A. (2014). Novel application of mixed hydrotropic solubilization technique in the formulation and evaluation of hydrotropic solid dispersion of aceclofenac. Asian Journal of Pharmaceutics (AJP), 4(3).


Vasanthavada M, Tong WQ, Serajuddin Abu TM. Water-insoluble drug

formulation. London: CRS press; 2008; p. 500-20.

Rao MG, Suneetha R, Sudhakara P, Reddy S, Ravi TK. Preparation

and evaluation of solid dispersion of naproxen. Indian J Pharm Sci


Saha RN, Sajeev C, Priya KP, Sreekhar C, Shashikant G. Solubility

enhancement of nimesulide and ibuprofen by solid dispersion

technique. Indian J Pharm Sci 2006;67:529-34.

Arias MJ, Moyano JR, Gines JM. Study by DSC and HSM of the

oxazepam-PEG 6000 and oxazepam-D mannitol system: Application

to the preparation of solid dispersion. Thermochimica Acta; 1998:


Varma MM, Pandit JK. Influence of urea and xylitol on the dissolution

rate of flurbiprofen. Indian Pharmacist; 2005:97-9.

Mooter GV, Verheyen S, Blaton N, Kinget R. Mechanism of dissolution

of diazepam and temazepam from polyethylene glycol 6000 solid

dispersion. Int J Pharm 2002;249:45-8.

Madhusudhan B, Rambhau D, Gudsoorkar VR, Shete JS, Apte SS. Studies

on sulphamethoxazole solid dispersion and their tablets. Indian J Pharm

Sci 2000;67:233-8.

Arias MJ, Gines JM, Moyano JR, Perez-Martinez JI, Rabasco AM. Influence

of preparation method of solid dispersions on their dissolution rate:

Study of triamterene-D-mannitol system. Int J Pharm Sci 1995;123:


Maheshwari RK. Solid dispersion and syrup formulation of poorly

water-soluble drug by hydrotropy. Indian Pharmacist 2006;5:


Maheshwari RK. Mixed hydrotropy in spectrophotometric analysis of

poorly water-soluble drug. Indian Pharmacist 2007;6:66-7.

British Pharmacopoeia. Vol. 3. 2002. p. 34-5.