Mixed solvency concept in reducing surfactant concentration of self‐emulsifying drug delivery systems of candesartan cilexetil using D‐optimal mixture design

Main Article Content

Chandna Chandan
Maheshwari RK

Abstract

The objective of this present study was to explore the utility of “mixed solvency†concept to enhance the solubility of poorlyâ€water soluble drug, candesartan cilexetil (CC) in modified solubilizer system. The objective of this paper is to
reduce the surfactant concentration traditionally involved in the formulation of selfâ€emulsifying drug delivery systems (SEDDS) by proposing an alternate system of solubilizer to provide novel surfactant/cosurfactant system, to aid traditionally involved components in the formulation of SEDDS.The present study showed that “mixed solvency†concept was successfully employed in solubility enhancement of CC in (Transcutol P: B3Mix [1:1]) up to 303 mg/g of blend. Present study demonstrated the promising use of “mixed solvency†concept in solubility enhancement of poorlyâ€water soluble drugs and tool to reduce the net surfactant concentration employed in designing of SEDDS.

Downloads

Download data is not yet available.

Article Details

How to Cite
Chandan, C., & RK, M. (2014). Mixed solvency concept in reducing surfactant concentration of self‐emulsifying drug delivery systems of candesartan cilexetil using D‐optimal mixture design. Asian Journal of Pharmaceutics (AJP), 7(2). https://doi.org/10.22377/ajp.v7i2.31
Section
Articles

References

Gursoy RN, Benita S. Selfâ€emulsifying drug delivery systems (SEDDS)

for improved oral delivery of lipophilic drugs. Biomed Pharmacother

;58:173â€82.

Hauss DJ. Oral Lipidâ€Based Formulations Enhancing the Bioavailability

of Poorly Waterâ€Soluable Drugs. New York, NY: Informa Healthcare

USA; 2007.

Pouton CW. Lipid formulations for oral administration of drugs:

Nonâ€emulsifying, selfâ€emulsifying and ‘selfâ€microemulsifying’ drug

delivery systems. Eur J Pharm Sci 2000;11 Suppl 2:S93â€8.

Pouton CW, Porter CJ. Formulation of lipidâ€based delivery systems for

oral administration: Materials, methods and strategies. Adv Drug Deliv

Rev 2008;60:625â€37.

Tang JL, Sun J, Guiâ€He Z. Selfâ€Emulsifying drug delivery systems: Strategy

for improving oral delivery of poorly soluble drugs. Curr Drug Ther

;2:85â€93.

Craig DQ, Barker SA, Banning D, Booth SW. An investigation into

the mechanisms of selfâ€emulsification using particle size analysis and

low frequency dielectric spectroscopy. Int J Pharm 1995;114:103â€10.

Strickley RG. Solubilizing excipients in oral and injectable formulations.

Pharm Res 2004;21:201â€30.

Tang B, Cheng G, Gu JC, Xu CH. Development of solid selfâ€emulsifying

drug delivery systems: Preparation techniques and dosage forms. Drug

Discov Today 2008;13:606â€12.

Dressman JB, Lennernas H. Oral Drug Absorption Prediction and

Assessment. New York: Marcel Dekker; 2000.

Singhai AK, Jain S, Jain NK. Cosolvent solubilization and formulation

of an aqueous injection of ketoprofen. Pharmazie 1996;51:737â€40.

Jouyban A, Fakhree MA. A new definition of solubilization power of a

cosolvent. Pharmazie 2008;63:317â€9.

Maheshwari RK. Mixedâ€solvencyâ€A novel concept for solubilization of

poorly waterâ€soluble drugs. J Technol Eng Sci 2009;1:39â€44,

Maheshwari RK. Mixedâ€solvency approachâ€Boon for solubilization of

poorly waterâ€soluble drugs. Asian J Pharm 2010;4:60â€3.

Maheshwari RK, Rajagopalan R. Solubilization of ibuprofen by

mixedâ€solvency approach. Indian Pharm 2009;8:81â€4.

Maheshwari RK, Rajagopalan R. Formulation and evaluation of

paracetamol syrup made by mixed solvency conceptâ€. Der Pharmacia

Lettre 2012;4:170â€4.

Maheshwari RK, Upadhyaya N, Jain J, Patani M, Mathuria K. New

spectrophotometric estimation of naproxen tablet formulations

employing mixedâ€solvency concept (at 331 nm). Int J Pharm Technol

;3:3618â€23.

Maheshwari RK, Shilpkar R. Formulation development and evaluation

of injection of poorly soluble drug using mixed solvency concept. Int

J Pharma Bio Sci 2012;3:179â€89.

Maheshwari RK, Agarwal A, “Formulation development and evaluation

of in situ nasal gel of poorly water soluble drug using mixed solvency

concept,†Asian J Pharm 2011;5:131â€40.

Maheshwari RK. Solid dispersion and syrup formulation of poorly water

soluble drug by hydrotropy. Indian Pharm 2006;5:87â€90.

Maheshwari RK, Rajput MS, Sharma S, Nair V. New spectrophotometric

determination of hydrochlorothiazide in tablets using mixed

hydrotropic solubilization technique. Der Pharmacia Lettre 2010;2:70â€4.

Gao P, Witt MJ, Haskell RJ, Zamora KM, Shifflett JR. Application of a

mixture experimental design in the optimization of a selfâ€emulsifying

formulation with a high drug load. Pharm Dev Technol 2004;9:301â€9.