Formulation and characterization of fast-dissolving tablet of promethazine theoclate
Main Article Content
superdisintegrants Ac-Di-Sol, Sodium Starch Glycolate (SSG), and Crospovidone in different concentrations. Nine formulations having superdisintegrants at different concentration levels were prepared to assess their efficiency and critical concentration level. Different types of evaluation parameters for tablets were used. Tablets containing Ac- Di- Sol showed superior organoleptic properties, along with excellent in vitro and in vivo dispersion time and drug release, as compared to other formulations.
Key words: Direct compression, promethazine theoclate, superdisintegrant
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.
Medical Economics Company. PhysicianÂ’s Desk Reference. 57th ed.
Stamford, CT: Thomson Healthcare; 2003;3432-3.
Seager H. Drug-deliver products and the zydis fast-dissolving dosage
form. J Pharm Pharmacol 1998;50:375-82.
Chiou WL, Riegelman S. Pharmaceutical applications of solid dispersion
systems. J Pharm Sci 1971;60:1281-302.
Habib W, Khankari R, Hontz J. Fast-dissolving drug delivery systems.
Crit Rev Ther Drug Carr Syst 2000;17:61-72.
Babu GV, Kumar NR, Himasankar K, Seshasayana A, Murthy KV.
Nimesulide-modified gum karaya solid mixtures: Preparation,
characterization and formulation development. Drug Dev Ind Pharm
Arias MJ, GinÃ©s JM, Moyano JR, PÃ©rez-MartÃnez JI, Rabasco AM. Influence
of preparation method of solid dispersions on dissolution rate: study
of triammterene-D-mannitol system. Int J Pharm 1995;123:25-31.
Yunxia B, Sunada H, Yonezawa Y, Danjo K, Evaluation of rapid
disintegrating tablets prepared by direct compression method. Drug
Dev Ind Pharm 1999;25:571.
Kuchekar BS, Arumugam V. Fast dissolving tablets. Indian J Pharm Edu