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root extract. It makes a convenient method for the green synthesis of AgNPs and evaluated for its wound healing activity.
Silver has been used for the treatment of medical ailments for over 100 years due to its natural antibacterial and antifungal
properties. The synthesized nanoparticles were characterized using UVâ€‘visible spectrophotometer; transmission electron
microscopy, Xâ€‘ray diffraction (XRD), scanning electron microscopy, and Fourier transform infraâ€‘red spectrometry. The
nanoparticles were found to be mostly spherical in shape. XRD study shows that the particles are crystalline in nature with
face centered cubic geometry. The synthesized AgNPs exhibited good antibacterial potential against both Gramâ€‘positive and
Gramâ€‘negative bacterial strain as measured using well diffusion assay. The recent emergence of nanotechnology has provided
a new therapeutic modality in AgNPs for use in wounds. We investigated the woundâ€‘healing potential of AgNPs hydrogel
using A. nobilis root extract in an excision animal model. The study showed that hydrogel of AgNPs using A. nobilis root extract
exert positive effect due to their antimicrobial potential. The results provide insight into the mechanism of actions of AgNPs
and have provided a novel therapeutic direction for wound treatment in the clinical practice.
Key words: Antibacterial potential, Arnebia nobilis, Fourier transform infraâ€‘red, silver nanoparticles, wound healing, Xâ€‘ray diffraction
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