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Background: Pleurotus ostreatus, the oyster mushroom, is primarily an edible mushroom with high nutritional
value and biomedical relevance, as it contains numerous bioactive components that generate the development of
therapeutic effects. Aim: The purpose of this study is to determine the phytopharmacological effects of P. ostreatus.
Material and Methods: To depict the medicinal properties of oyster mushroom, FTIR, HPLC, GC-MS, anticancer
and antimicrobial activities were conducted. Results: The presence of 12 bioactive compounds was revealed
using gas chromatography-mass spectrometry, and components in the extract were identified and quantified
using high pressure liquid chromatography. The extract’s anticancer efficacy against HeLa and MCF-7 at 25 μg/
ml and exhibits strong cytotoxicity activity of 6.8 μg/mL and 17.5 μg/mL, respectively. Antimicrobial efficacy
of P. ostreatus aqueous extract against Bacillus megaterium and Bacillus amyloliquefaciens seems promising.
A significant inhibitory zone was discovered against B. megaterium at 90 μg/ml of sample. Conclusion: Our
primary data from this research work can help in the detection of bioactive component’s, the determination of their
efficacy through in vivo research, and the demonstration of their safety and efficacy in clinical trials.
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