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between 123Â±8.35 Î¼m and 524Â±11.54 Î¼m. Percent drug entrapment and release profiles of amoxicillin trihydrate in 0.1 N HCl were determined using high-performance liquid chromatography.The percentage drug entrapment and percentage yield of formulations were about 56.71Â±1.66% to 88.32Â±0.65% and 39.20Â±1.62% to 92.40Â±1.32%, respectively.The stability of the drugs was assessed in 0.1 N HCl. The results further substantiated that mucoadhesive microspheres improved the gastric stability of amoxicillin trihydrate (due to entrapment within the microsphere). From the above results, it was concluded
that the mucoadhesive microspheres of amoxicillin trihydrate has feasibility for eradicating H. pylori from the stomach more effectively because of the prolonged gastrointestinal residence time and controlled release of drug from the formulation.
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