Formulation and evaluation of floating tablets of niacin for sustained release

Main Article Content

Haripriya Puthoori
TEGK Murthy
Atul Kaushik
Murthy K2

Abstract

Niacin or nicotinic acid (NA) is used in the treatment of hyperlipidemia. NA immediate release formulation shows undesirable effects like flushing of the face and neck parts. In the present study, NA floating sustained release dosage
form was developed to prolong the drug release, to retain the drug delivery system above the site of absorption for the desired period of time, and to reduce the drug release rate compared to conventional formulations in order to minimize the side effects. The preformulation parameters such as flow properties and drug-excipient compatibility studies were performed. The drug excipient compatibility studies were performed using the FTIR study and the results showed that all the polymers used in the study are compatible with the pure drug. The floating sustained release tablets of niacin were prepared by the wet granulation method and the granules were evaluated for various micromeritic properties like bulk density, tapped density, Carr’s Index, Hausner’s ratio, and angle of repose. The tablets were evaluated for post-compressional parameters like average weight, thickness, hardness, friability, swelling index, floating lag time and total floating time, and in vitro drug release studies. All the formulations showed total floating time >20 hr. The concentration of the effervescent agent and the
concentration and type of polymer showed an effect on the floating behavior and drug release. The formulation containing 13% sodium bicarbonate, HPMC (33%) and Eudragit RS PO (4%) showed required drug release up to 20 hr.

Downloads

Download data is not yet available.

Article Details

How to Cite
Puthoori, H., Murthy, T., Kaushik, A., & K2, M. (2014). Formulation and evaluation of floating tablets of niacin for sustained release. Asian Journal of Pharmaceutics (AJP), 6(1). https://doi.org/10.22377/ajp.v6i1.70
Section
Articles

References

Shah SH, Patel JK, Patel NV. "Stomach specific floating drug delivery

system: A review". Int J Pharm Tech Res 2009;1:623-33.

Dehghan MHG, Khan FN. Gastroretentive drug delivery systems

A patent perspective. Int J Health Res 2009;1:23-44.

Cholesterol management with drugs. Available from: http//www.accessdata. fda.gov/scripts/cder/drugs altd/. [Last accessed on 2011 Oct 15].

Shinde G. Formulation and evaluation of mucoadhesive tablets of

niacin using different bioadhesive polymers. Int J Pharma Biosci 2012;1.

Available from: www.ijpbs.net. [Last accessed on 2011 Oct 15].

Available from: http//www.druglib.com/niacin/htm. [Last accessed on

Oct 15]

Available from: http//www.rxlist.com/cgi/generic/nicotinicacid.htm.

[Last accessed on 2011 Oct 15].

Available from: http//www.drugbank.com/nicotinicacid/htm. [Last

accessed on 2011 Oct 15].

Turner S, Federici C, Hite M, Fassihi R. Formulation development and

human In vitro-In vivo correlation for a novel, monolithic controlled

release matrix system of high load and highly water-soluble drug

niacin. Drug Dev Ind Pharm 2004;30:797-807. Available from: http//

informahealthcare.com/doi/abs/10.1081/DDC-200026747. [Last

accessed on 2011 Oct 15].

Maravajhala V, Dasari N, Sepuri S, Joginapalli S. Design and evaluation

of niacin microshperes. Indian J Pharm Sci 2009;71:663-9. [Last accessed

on 2011 Oct 15]. Available from: http//www.ncbi.nlm.nih.gov/pmc/

articles/PMC2846472/. [Last accessed on

Available from: http//www.uspbpep.com/search.asp. [Last accessed on

Oct 15].

Available from: http//www.slideboom.com/presentations/288556/

Methods-to-evaluate-compatibility-of-drugs-with-excipients. [Last

accessed on 2011 Oct 15].

Sonar GS, Jain DK, More DM. Preparation and In vitro Evaluation of

bilayer floating-bioadhesive tablets of rosiglitazone maleate. Asian J

Pharm Sci 2007;2:161-9.

Raval JA, Patel JK, Naihong Li, Patel MM. Ranitidine hydrochloride

floating matrix tablets based on low density powder: Effects of

formulation and processing parameters on drug release. Asian J Pharm

Sci 2007;2:130-42.

Tiwari SB, Murthy TK, Pai MR, Mehta PR, Chowdary PB. Controlled

release formulation of tramadol hydrochloride using hydrophilic and

hydrophobic matrix system. AAPS PharmSciTech 2003;4:E31.

ICH guidelines for accelerated stability studies. Available from:

http//www.ikev.org/haber/stabilite/kitap/29%201.1%20Stability%20

Workshop%20ICH%20Q1AR2%20C.pdf. [Last accessed on 2011 Oct 15].

Jonas Ide. Eudragit application guidelines", Degussa Publications,

Pharma Polymers, 10 th ed, 2007. Available from: http//www.

pharmapolymers.com. [Last accessed on 2011 Oct 15].

Mi-chia Ma, Ru-pyng Lin, Jen-pei Liu. Statistical evaluation of dissolution similarity. Stat Sin 1999;9:1011-27.

Available from: http://www.freepatentsonline.com/20100240889/

niaspan/pdf. [Last accessed on 2011 Oct 15].