Characterization of cylindrical and strip-shaped tamoxifen citrate-loaded biodegradable implants

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Jagadeesh G Hiremath
Pragnesh B Patel
Rajesh Kumar Aitha
Prasanthkumar Mura
Subhash Palavalli G


The aim of this study was to prepare tamoxifen citrate (TC)-loaded cylindrical and strip-shaped polymeric subdermal implants. The implant was based on poly(ε-caprolactone), a low-melting, biodegradable and biocompatible polymer.
Polyethylene glycol (PEG 4000) was used to enhance solubility and release of the drug in the phosphate buffer saline pH 7.4. Implants were prepared by a standardized melt manufacturing method. The prepared implants were evaluated for their physicochemical parameters and drug content in implants by UV spectrophotometric method. PCL-based implants were characterized by Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry, X-ray diffraction studies(XRD) and scanning electron microscopy (SEM). DSC studies showed that the TC in the implants was in the amorphous state. In vitro drug release studies were performed in methanol:phosphate-buffered saline (pH 7.4) at 37±2°C by using horizontal water bath shaker. Stability study was carried out for 90 days, there was no significant change in drug content
and other parameters of the PCL-based formulations.


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Hiremath, J. G., Patel, P. B., Aitha, R. K., Mura, P., & G, S. P. (2014). Characterization of cylindrical and strip-shaped tamoxifen citrate-loaded biodegradable implants. Asian Journal of Pharmaceutics (AJP), 5(4).


Siepmann J, Siepmann F, Florence AT. Local controlled drug delivery

to the brain: mathematical modeling of the underlying mass transport

mechanisms. Int J Pharm 2006;314:101-19.

Ruixia Yu, Hualing C, Tianning C, Xiangyang Z. Modeling and simulation

of drug release from multi-layer biodegradable polymer microstructure

in three dimensions. Simul Model Pract Theory 2008;16:15-25.

Siepmann J, Siepmann F. Mathematical modeling of drug delivery. Int

J Pharm 2008;364:328-43.

Fialho SL, Behar-Cohen F, Silva-Cunha A. Dexamethasone-loaded

poly(epsilon-caprolactone) intravitreal implants: a pilot study. Eur J

Pharm Biopharm 2008;68:637-46.

Cheng Z, Teoh SH. Surface modification of ultra thin poly (epsilon-

caprolactone) films using acrylic acid and collagen. Biomaterials


Furr BJ, Jordan VC. The pharmacology and clinical uses of tamoxifen.

Pharmacol Ther 1984;25:127-205.

Park WC, Jordan VC. Selective estrogen receptor modulators

(SERMS) and their roles in breast cancer prevention. Trends Mol Med


Tamoxifen citrate (Nolvadex1) product label. Available from: http:// [Last accessed 2012 Feb 22].

Hiremath JG, Devi KV, Devi K, Domb AV. Biodegradable Poly (sebacic acid- co-ricinolic ester anhydride) tamoxifen citrate implants: preparation

and in vitro characterization. J Appl Polym Sci 2008;107:2745-54.

Cheng L, Guo S, Wu W. Characterization and in vitro release of

praziquantel from poly(epsilon-caprolactone) implants. Int J Pharm


Mei L, Sun H, Song C. Local delivery of modified paclitaxel-loaded

poly(epsilon-caprolactone)/pluronic F68 nanoparticles for long-term

inhibition of hyperplasia. J Pharm Sci 2009;98:2040-50.

Rothen-Weinhold A, Besseghir K, Vuaridel E, Sublet E, Oudry N, Kubel F,et al. Injection-molding versus extrusion as manufacturing technique

for the preparation of biodegradable implants. Eur J Pharm Biopharm


Costa P, Sousa Lobo JM. Modeling and comparison of dissolution

profiles. Eur J Pharm Sci 2001;13:123-33.