Paclitaxel loaded biodegradable poly (sebacic acid‐co‐ricinoleic acid) cylindrical implants for local delivery‐in vitro characterization

Jagadeesh G Hiremath, V Kusum Devi

Abstract


The aim of the present research work was to develop the biodegradable polymeric implant for the delivery of antineoplasticdrug, paclitaxel (PTX) using poly (sebacic‐co‐recinoleic acid) 70:30 w/w. PTX loaded implants were prepared by
indigenously developed melt molding technique. Implants were characterized in terms of physico‐chemical evaluations, drug content, drug stability and intactness, thermal analysis, drug physical state and crystallinity, surface morphology, hydrolytic degradation, drug release and its kinetics. Prepared implants were yellow and cylindrical in shape with smooth surfaces.Drug in the implants was found to be stable, intact and uniformly dispersed as amorphous state within the polymer matrix.
In vitro release, kinetic studies showed zero order and Korsmeyer‐Peppas model release being exhibited. Drug release from the polymeric implants was occurred could be as results of diffusion.


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DOI: http://dx.doi.org/10.22377/ajp.v7i3.20

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