Formulation and evaluation of pectin-hydroxypropyl methylcellulose coated curcumin pellets for colon delivery

Main Article Content

R Sureshkumar
Munikumar Munikumar
G N K Ganesh
N Jawahar
D Nagasamyvenkatesh
V Senthil
L Raju
M K Samantha


High molecular weight hydroxypropyl methylcellulose (HPMC) and biodegradable pectin were used for coating the pellets containing curcumin, to be released in the colon. The prepared pellets were freeflowing. in vitro release of curcumin
remained intact up to pH 3.0, disintegrated at pH 7.2, and released up to 12 hours. The ideal batch (1:3) showed minimum release at pH 1.2 and maximum release at pH 6.8, and an increased amount of curcumin in the blood stream(1.287 μg/ml)
was achieved when compared with pure curcumin (0.5 μg/ml). The drug release was retarded by the high concentrationand greater thickness of the coating of HPMC on the pellets. Release kinetics of the preparation shows a non-Fickian or
anamolous diffusion or matrix erosion.


Download data is not yet available.

Article Details

How to Cite
Sureshkumar, R., Munikumar, M., Ganesh, G. N. K., Jawahar, N., Nagasamyvenkatesh, D., Senthil, V., Raju, L., & Samantha, M. K. (2014). Formulation and evaluation of pectin-hydroxypropyl methylcellulose coated curcumin pellets for colon delivery. Asian Journal of Pharmaceutics (AJP), 3(2).


Watts PJ, Illum L. Colonic drug delivery. Drug dev Ind Pharm


Busseimeier T, Otto I, Bodmier R. Pulsatile drug delivery systems. Crit

Rev Ther Drug Carrier Syst 2001;18:433-58.

Vandamme TF, Lenourry A, Charrueau C, Chaumeil JC. The use of

polysaccharides to target drugs to colon. Carbohydrate polymers


Kshirsagar NA. Drug delivery systems. Indian J Pharmacol 2000;32:54-61.

Friend DR. Colon-specific drug delivery. Adv Drug Del Rev 1991;7:149-99.

Yang L, Chu JS, Fix JA. Colon-specific drug delivery: new approaches

and in vitro/in vivo evaluation. Int J Pharm 2002;235:1-15.

Rubinstein A. Approaches and opportunities in colon specific drug

delivery. Crit Rev Ther Drug Carrier Syst 1995;12:101-49.

Tozer TN, Irend DR, McLeod AD. Kinetic perspective on colonic drug

delivery. STP Pharma Sci 1995;5:5-28.

Gupta VK, Beckret TE, Price JC. A novel pH and time based multi-unit

potential colonic drug delivery system. I. Development. Int J Pharm


Prasad YV, Krishnaiah YS, Sathyanarayana S. In vitro evaluation of guargum as a carrier for colon specific drug delivery. J Control Release


Kinget R, Kalale W, Veervoort L, van den Mooter G. Colonic drug

targeting. J Drug Target 1998;6:129-49.

Sarasija S, Hota A. Colon specific drug delivery systems. Indian J PharmSci 2000;62:1-8.

Mrsny RJ. The colon as a site for drug delivery. Control Release


Vender mooter G, Kinget R, Taludar MM. In vivo evaluation of xanthum

gum as a potential excipient for oral controlled release matrix tablet

formulation. Int J Pharm Sci 1998;169:105-13.

Schacht E, Wilding I. Process for the preparation of azo-and/or disulfide

containing polymers. 1993, Patent EP: 0513035.

Sintov A, Ankol S, Levy DP, Rubinstein A. Synthesis and in vitro evaluation

of a new biodegradable polymer for colon specific drug delivery

purposes. Pharmaceutical Research 1992;9: 231.

Chourasia MK, Jain SK. Pharmaceutical approaches to colon targeted

drug delivery systems. J Pharm Pharma Sci 2003;6:33-66.

Khan MZ, Prebeg Z, Kurjakovic N. A pH-dependent colon targeted

oral drug delivery system using methacrylic acid copolymers. I.

Manipulation oOf drug release using Eudragit L100-55 and Eudragit

S100 combinations. J Control Release 1999;58:215-22.

Kramer A, Turk S, Vrecer F. Statistical optimization of diclofenac

sustained release pellets coated with polymeric films. Int J Pharm


Johnson JJ, Mukhtar H. Curcumin for chemoprevention of colon cancer.

Cancer Lett 2007; 255:170-81.

Turkoglu M, Ugurlu T. In vitro evaluation of pectin-HPMC compression

coated 5-aminosalicylic acid tablets for colonic delivery. Eur J Pharm

Biopharm 2002;53:65-73.

Beatrice NC, Mark W, Paul M, Moji CA. Feasibility studies in

spheronisation and scale-up of ibuprofen micro particles using the

rotor disc fluid bed technology. Pharm Sci Tech 2002;3:1-13.

Lucy SC, Lai WF. Factors affecting drug release from drug coated

granules prepared by fluidized bed coating. Int J Pharm 1991;72:163-74.

Vervaet C, Remon JP. Influence of impeller design, method of screen

perforation and perforation geometry on the quality of pellets made

by extrusion-spheronisation. Int J Pharm 1996; 133:29-37.

Maiti K, Mukherjee K, Gantait A, Saha BP, Mukherjee PK. Curcumin-

phospholipid complex: Preparation, therapeutic evaluation and

pharmacokinetic study in rats. Int J Pharm 2007;330:155-63.