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content, buccoadhesive strength and the P-value statistically significant at <0.05. Ex vivo mucous irritation by histological examination reveals, the administration site of buccal tablet over the buccal mucosa did not cause any irritation, ulceration, inflammation and redness, and it resembles to controlled buccal mucosa. Good correlations were observed between in vitro and in vivo drug release, with a correlation coefficient of 0.996. Drug diffusion from buccal tablets showed apparently zero order kinetics and release mechanism was diffusion controlled after considerable swelling.
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Goodman and Gilmans. The pharmacological basis of therapeutics. 11th
ed. New York: McGraw Hill Medical Publishing Division; 2006. p. 971-2.
Jaimini M, Rana AC, Tanwar YS. Formulation and evaluation of
famotidine floating tablets. Curr Drug Deliv 2007;4:51-5.
McQuaid KR. Drugs used in the treatment of gastrointestinal diseases.
In: Katzung BG, editor. Basic and clinical pharmacology. 9th ed. Asia:
The McGraw-Hill Companies. Inc; 2004. p. 1036.
Kim TH, Ahn JS, Choi HK, Cho CS. A novel mucoadhesive polymer film
composed of carbopol, poloxamer and hydroxypropylmethylcellulose.
Arch Pharm Res 2007;30:381-6.
Sahni J, Raj S, Ahmad FJ, Khar RK. Design and invitro characterization
of buccoadhesive delivery system of insulin. Indian J Pharm Sci
Semalty A, Semalty M, Singh R, Saraf SK, Saraf S. Properties and
formulation of oral drug delivery of protein and peptides. Indian J
Pharm Sci 2007;69:741-7.
The United States Pharmacopeia, 29th Ed. and The National Formulary24th ed. The United States Pharmacopeial Convention Rockville, MD,prepared by the council of experts and published by the Board of
Trustee printed in Canada by Webcom Limited. Toronto; 2005. p.
Samani SM, Najafi R, Yousefi G. Formulation and in vitro evaluation of
prednisolone buccoadhesive tablets. Farmaco 2005;60:339-44.
Nafee NA, Ismail FA, Boraie NA, Mortada LM. Mucoadhesive buccal
patches of miconazole nitrate â€“ in vitro/in vivo performance and effect
of ageing. Int J Pharm 2003;264:1-14.
Desai KG, Kumar TM. Preparation and evaluation of a Novel Buccal
adhesive system. AAPS Pharm Sci Tech 2004;5:1-9.
Pramod Kumar TM, Shivakumar HG, Desai KG. Oral transmucosal drug
delivery systems. Indian Drugs 2004;41:63-72.
Patl VM, Prajapati BG, Patel MM. Formulation, evaluation and
comparison of bilayered and multilayered mucoadhesive buccal devices
of Propranolol hydrochloride. AAPS Pharm Sci Tech 2007;8:E1-8.
Sahini J, Raj S, Ahmad F, Khar RK. Design and in vitro characterization
of buccoadhesive drug delivery system of insulin. Indian J Pharm Sci
Singh B, Ahuja N. Development of controlled release buccoadhesive
hydrophilic matrices of diltiazem hydrochloride: Optimization of
bioadhesion, dissolution and diffusion parameters. Drug Dev Ind
Miyazaki S, Kawasaki N, Nakamura T, Iwatsu M, Hayashi T, Hou WM,
et al. Oral mucosal bioadhesive tablets of pectin and HPMC: in vitro and
in vivo evaluation. Int J Pharm 2000;204: 127-32.
Ribeiro L, Ferreira DC, Veiga FJ. In vitro controlled release of
vinpocetineâ€“cyclodextrinâ€“tartaric acid multicomponent complexes
from HPMC swellable tablets. J Control Release 2005;103:325-39.
Shanker G, Kumar CK, Gonugunta CS, Kumar BV, Veerareddy PR.
Formulation and evaluation of bioadhesive buccal drug delivery of
tizanidine hydrochloride tablets. AAPS Pharmscitech 2009;10:530-9.
Giannola LI, De Caro V, Giandalia G, Siragusa MG, Tripodo C, Florena
AM, et al. Release of Naltrexone on buccal mucosa: Permeation studies,
histological aspects and matrix system design. Eur J Pharm Biopharm
Shin SC, Bum JP, Choi JS, Enhanced bioavailability by buccal
administration of Triamcinolone Acetonide from the bioadhesive gels
in rabbits. Int J Pharm 2000;209:37-43.
Nakhat PD, Kondawar AA, Babla IB, Rathi LG, Yeole PG. Studies on
buccoadhesive tablets of terbutaline sulphate. Indian J Pharm Sci